%0 Journal Article
%T Association between sarcoidosis and cardiovascular Outcomes: A systematic review and Meta-analysis.
%A Jaiswal V
%A Peng Ang S
%A Sarfraz Z
%A Butey S
%A Vinod Khandait H
%A Song D
%A Ee Chia J
%A Maroo D
%A Hanif M
%A Ghanim M
%A Chand R
%A Biswas M
%J Int J Cardiol Heart Vasc
%V 41
%N 0
%D Aug 2022
%M 35800042
暂无%R 10.1016/j.ijcha.2022.101073
%X <B>UNASSIGNED: </B>Sarcoidosis is a chronic inflammatory disorder of unknown etiology associated with high morbidity and mortality. Its association with cardiovascular outcomes is under-documented.<BR><B>UNASSIGNED: </B>The aim of this study was to assess the adverse cardiovascular outcomes in patients with sarcoidosis compared with that of non-sarcoidosis.<BR><B>UNASSIGNED: </B>Online databases including PubMed, Embase and Scopus were queried from inception until March 2022. The outcomes assessed included all-cause mortality (ACM) and incidence of ventricular tachycardia (VT), heart failure (HF) and atrial arrhythmias (AA).<BR><B>UNASSIGNED: </B>A total of 6 studies with 22,539,096 participants (42,763 Sarcoidosis, 22,496,354 Non-Sarcoidosis) were included in this analysis. The pooled prevalence of sarcoidosis was 13.1% (95% CI 1% to 70%). The overall mean age was 47 years. The most common comorbidities were hypertension (12.7% vs 12.5%), and diabetes mellitus (5.5% vs 4%) respectively. The pooled analysis of primary endpoints showed that all-cause mortality (RR, 2.08; 95% CI: 1.17 to 3.08; p = 0.01) was significantly increased in sarcoidosis patients. The pooled analysis of secondary endpoints showed that the incidence of VT (RR, 15.3; 95% CI: 5.39 to 43.42); p < 0.001), HF (RR, 4.96; 95% CI: 2.02 to 12.14; p < 0.001) and AA (RR, 2.55; 95% CI: 1.47 to 4.44); p = 0.01) were significantly higher with sarcoidosis respectively compared to non-sarcoidosis.<BR><B>UNASSIGNED: </B>Incidence of VT, HF and AA was significantly higher in patients with CS. Clinicians should be aware of these adverse cardiovascular events associated with sarcoidosis.