%0 Case Reports
%T Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders - Outcome After Hematopoietic Stem Cell Transplantation.
%A Baumann U
%A Schulte JH
%A Groß JP
%A Beier R
%A Ludwig M
%A Wahn V
%A Hofmann J
%A Maecker-Kolhoff B
%A Sauer M
%A Kaiser-Labusch P
%A Karimian N
%A Blume-Peytavi U
%A Ghoreschi F
%A Ott H
%A Perelygina L
%A Klemann C
%A Blankenstein O
%A von Bernuth H
%A Krüger R
%J Front Immunol
%V 13
%N 0
%D 2022
%M 35720367
%F 8.786
%R 10.3389/fimmu.2022.886540
%X We report two patients with DNA repair disorders (Artemis deficiency, Ataxia telangiectasia) with destructive skin granulomas, presumably triggered by live-attenuated rubella vaccinations. Both patients showed reduced naïve T cells. Rapid resolution of skin lesions was observed following hematopoietic stem cell transplantation. However, the patient with AT died due to complications of severe hepatic veno-occlusive disease 6 month after HSCT. Dried blood spots obtained after birth were available from this patient and showed absent T-cell receptor excision circles (TRECs). Therefore, newborn screening may help to prevent patients with moderate T-cell deficiency from receiving live-attenuated rubella vaccine potentially causing granulomas.