%0 Journal Article
%T Dectin-2 promotes house dust mite-skewed Th2 response through the activation of cDC2s.
%A Qu Y
%A Ma X
%A Deng J
%A Shang Y
%A Shang K
%A Wang X
%A Guo Z
%A Bai C
%J Cell Immunol
%V 378
%N 0
%D 08 2022
%M 35717749
%F 4.178
%R 10.1016/j.cellimm.2022.104558
%X The role of Dectin-2 (gene symbol, Clec4n) in house dust mite (HDM) induced Th2 immune response and the exact mechanism remains controversial. In this study, we illustrated that, Clec4n-/- mice had decreased Th2 immune response following HDM challenge, which may ascribe to dramatically reduced type 2 conventional dendritic cells (cDC2s) in lung of Clec4n-/- mice, as cDC2s from lung of Clec4n-/- mice after challenging had less ability to induce Th2 response with decreased production of IL-4/IL-13. Further in vitro experiments showed the activation of Clec4n-/--BMDCs significantly decreased after HDM stimulation accompanied with decreased activation of Syk-NF-κB and Syk-JNK signal pathway. Importantly, Dectin-2 expression in PBMCs from asthmatic patients was significantly higher than that in healthy controls. Taken together, these results demonstrated that Dectin-2 could promote cDC2s activation in lung, which polarizes Th2 immune response outlining a novel mechanism of asthma development.