%0 Journal Article
%T Chronic Nodular Prurigo: A Retrospective Study of 74 Cases.
%A Espiñeira Sicre J
%A Docampo Simón A
%A Silvestre Salvador JF
%J Actas Dermosifiliogr
%V 113
%N 9
%D Oct 2022
%M 35659612
暂无%R 10.1016/j.ad.2022.05.018
%X <B>OBJECTIVE: </B>Chronic nodular prurigo (CNPG) is a recently defined and currently underdiagnosed disease with a variety of causes. It is associated with multiple comorbidities, and its management and treatment have improved with a better understanding of its pathogenesis. The aim of this study was to describe our experience with a series of patients with CNPG.<BR><B>METHODS: </B>Single-center, observational, retrospective study of the sociodemographic and clinical characteristics of patients with CNPG seen at the dermatology department of a tertiary care hospital between 2009 and 2021.<BR><B>RESULTS: </B>We included 74 patients, mostly women (63.5%), with a mean age of 57 years. Overall, 39.2% of patients had a concomitant skin condition, mainly atopic dermatitis (62%). Other comorbidities included endocrine disorders (54.1%), cardiovascular disease (44.4%), and psychiatric disorders (36.5%). Skin biopsy helped confirm the clinical diagnosis in 70% of cases. The mean immunoglobulin E level was higher than normal (516 IU/mL), regardless of atopic predisposition. On average, patients received 3 treatments, the most common choices being methotrexate, antihistamines, and topical and oral corticosteroids. Methotrexate was among the most effective options.<BR><B>CONCLUSIONS: </B>CNPG is a complex disease associated with multiple comorbidities. It requires a multidisciplinary approach, with the dermatologist at the center. Classical treatment approaches are probably insufficient.