%0 Case Reports
%T Splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review.
%A Markovic U
%A Colarossi C
%A Iuppa A
%A Scire P
%A Gorgone A
%A Galbo F
%A Amato G
%A Moschetti G
%J J Int Med Res
%V 50
%N 5
%D May 2022
%M 35638556
%F 1.573
%R 10.1177/03000605221095504
%X Granulocyte-colony stimulating factors (G-CSFs) are the cornerstone of peripheral blood stem cell mobilization and apheresis. However, splenic rupture following G-CSF treatment represents a serious and potentially fatal adverse event. Here, we report the case of a patient in their late 50s with severe pancytopenia post-autologous stem cell transplantation reinfusion suffering from splenic rupture after treatment with lenograstim. We also reviewed the literature describing cases of splenic rupture during G-CSF administration.