%0 Journal Article
%T Structural insights into ORF10 recognition by ZYG11B.
%A Zhang B
%A Li Y
%A Feng Q
%A Song L
%A Dong C
%A Yan X
%J Biochem Biophys Res Commun
%V 616
%N 0
%D 08 2022 6
%M 35636250
%F 3.322
%R 10.1016/j.bbrc.2022.05.069
%X Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a major threat to human health. As a unique putative protein of SARS-CoV-2, the N-terminus of ORF10 can be recognized by ZYG11B, a substrate receptor of the Cullin 2-RING E3 ubiquitin ligase (CRL2). Here we elucidated recognition mechanism of ORF10 N-terminus by ZYG11B through presenting the crystal structure of ZYG11B bound to ORF10 N-terminal peptide. Our work expands the current understanding of ORF10 interaction with ZYG11B, and may also inspire the development of novel therapies for COVID-19.