%0 Journal Article
%T Radiation-induced Brain Calcification Leads to L-dopa-resistant Parkinsonism and Cerebellar Ataxia.
%A Shimada T
%A Kamo R
%A Daida K
%A Nishioka K
%A Hattori N
%A Tsunemi T
%J Intern Med
%V 61
%N 24
%D Dec 2022 15
%M 35598989
%F 1.282
%R 10.2169/internalmedicine.8400-21
%X We experienced a young patient who presented with progressive parkinsonism and cerebellar ataxia. Brain magnetic resonance imaging revealed progressive brain calcification, expanding from the bilateral basal ganglia to the central pons, caused by a delayed reaction to the radiation therapy that she had received to treat craniopharyngioma 14 years earlier. Heterogeneous clinical symptoms due to radiation-induced brain calcification have been described, but parkinsonism has never been reported. While dopamine transporter-single photon emission computed tomography revealed only slight damage to the dopaminergic striatal pathway, the extension of calcification to the periventricular white matter was likely responsible for her parkinsonism.