%0 Journal Article
%T Lateralized ante mortem and post mortem pathology in a case of Lewy body disease with corticobasal syndrome.
%A Coughlin DG
%A Coslett HB
%A Peterson C
%A Phillips JS
%A McMillan C
%A Lee EB
%A Trojanowski JQ
%A Grossman M
%A Irwin DJ
%J Alzheimers Dement (N Y)
%V 8
%N 1
%D 2022
%M 35592691
暂无%R 10.1002/trc2.12294
%X <B>UNASSIGNED: </B>Lewy body diseases are pathologically characterized by α-synuclein pathology. Alzheimer's disease (AD) co-pathology can influence phenotypes. In vivo AD biomarkers can suggest the presence of this co-pathology in unusual cases, but pathological validation remains essential.<BR><B>UNASSIGNED: </B>This patient originally presented with corticobasal syndrome and later developed visual hallucinations and parkinsonism consistent with a synucleinopathy. The patient underwent CSF sampling, 18F-flortaucipir PET scanning, and brain donation with bilateral regions available for digital histological analysis.<BR><B>UNASSIGNED: </B>CSF Aβ42 and t-tau were in the AD range. 18F-flortaucipir scanning showed right-lateralized retention in all lobes (t = 4.3-10.0, P < .006). Neocortical stage Lewy body pathology and high levels of AD neuropathological changes were present at autopsy. There was right lateralization of α-synuclein and tau pathology (T value = 3.1, P value = .007 and T value = 3.3, P value = .004 respectively).<BR><B>UNASSIGNED: </B>This case with overlapping tauopathy and synucleinopathy clinical features had in-depth biomarker characterization and rare bilateral post-mortem sampling showing lateralized tau and α-synuclein pathology suggesting possible synergistic relationships.