%0 Case Reports
%T Intracranial fungal Cladophialophora bantiana infection in a nonimmunocompromised patient: A case report and review of the literature.
%A Kilbourn KJ
%A Green J
%A Zacharewski N
%A Aferzon J
%A Lawlor M
%A Jaffa M
%J Surg Neurol Int
%V 13
%N 0
%D 2022
%M 35509580
暂无%R 10.25259/SNI_116_2022
%X <B>UNASSIGNED: </B>Cladophialophora bantiana is a dematiaceous fungus that rarely infects the central nervous system (CNS). It is associated with a mortality rate of over 70% despite treatment.<BR><B>UNASSIGNED: </B>An 81-year-old female with a remote history of renal cell carcinoma presented with progressive headache and an expressive aphasia for 3 days. Computed tomography imaging revealed a left frontotemporal mass with surrounding vasogenic edema. A left frontotemporal craniotomy was performed and cultures revealed C. bantiana. The initial management with IV voriconazole was unsuccessful and the patient had a recurrence of the cranial infection and developed pulmonary abscesses. Following the addition of oral flucytosine, the patient showed a significant improvement with a complete radiographic resolution of both the cranial and pulmonary lesions.<BR><B>UNASSIGNED: </B>C. bantiana involving the CNS is a rare and often fatal disease. Surgical management along with standard antifungal treatment may not provide definitive therapy. The addition of flucytosine to IV voriconazole resulted in a positive outcome for this patient who is alive, living independently 1 year from the original diagnosis. In this rare fungal infection, standard antifungal treatment may not provide adequate coverage and the utilization of additional therapy may be required.