%0 Case Reports
%T Controversial Flow Cytometry Monitoring of a Relapse Case of Pediatric T Cell Acute Lymphoblastic Leukemia: A Case Report.
%A Popa DC
%A Şerbănică A
%A Obrisca R
%A Şerbănică I
%A Radu L
%A Jercan C
%A Marcu A
%A Bica A
%A Asan M
%A Petran M
%A Dragomir M
%A Jardan C
%A Ţică V
%A Gheorghe A
%A Stoian I
%A Coriu D
%A Coliţă A
%A Coliţă A
%A Popa DC
%A Şerbănică A
%A Obrisca R
%A Şerbănică I
%A Radu L
%A Jercan C
%A Marcu A
%A Bica A
%A Asan M
%A Petran M
%A Dragomir M
%A Jardan C
%A Ţică V
%A Gheorghe A
%A Stoian I
%A Coriu D
%A Coliţă A
%A Coliţă A
%J Front Med (Lausanne)
%V 9
%N 0
%D 2022
%M 35391882
%F 5.058
%R 10.3389/fmed.2022.858809
%X Acute lymphoblastic leukemia (ALL) is the most frequent childhood cancer, with 80-85% represented by B cell ALL and only 15% by T cell ALL. T Cell ALL (T-ALL) carries a more reserved prognosis compared to B Cell ALL (B-ALL) with regard to response to treatment, risk of relapse, and overall survival. Progress made in current monitoring protocols such as via flow cytometry immunophenotyping (FCM) and by PCR-based amplification of antigen-receptor genes led to improved management of patients with ALL and superior rates of survival. Nevertheless, challenges remain in some clinical cases. This manuscript describes a unique case of T-ALL and raises awareness of such clinical challenges. The article presents an overview of the flow cytometry immunophenotyping at diagnosis and during treatment of a pediatric patient with T-ALL from Fundeni Clinical Institute. In this case, in spite of various therapeutic measures such as first-line chemotherapy for high risk group, salvage chemotherapy (FLAG), conditioning regimen (FLU-BU-TT-ATG), and stem cell transplant, a chemoresistance clone continued to be present.