%0 Journal Article
%T A review of physiological resistance to insecticide stress in Nilaparvata lugens.
%A Tang B
%A Xu K
%A Liu Y
%A Zhou Z
%A Karthi S
%A Yang H
%A Li C
%J 3 Biotech
%V 12
%N 3
%D Mar 2022
%M 35251886
%F 2.893
%R 10.1007/s13205-022-03137-y
%X Insecticides are widely used in agriculture as effective means to control pests. However, pests have not been completely mitigated with the increased use of insecticides. Instead, many side effects have arisen, especially the '3Rs' (resistance, resurgence, and residue). The brown planthopper, Nilaparvata lugens, is one of the most threatening rice pests. The main insecticides for controlling N. lugens belong to organochlorine, organophosphorus, carbamate, neonicotinoid and pyrethroid groups. However, metabolic enzymes, including cytochrome P450s, esterases, glutathione-S-transferases, and ATP-binding cassette transporters, effectively promote the detoxification of insecticides. Besides, mutations of neurological target sites, such as acetylcholinesterase, nicotinic acetylcholine, γ-aminobutyric acid receptor, and ryanodine receptor, result in insensitivity to insecticides. Here, we review the physiological metabolic resistance in N. lugens under insecticide stress to provide a theoretical basis for identifying and developing more effective and harmless insecticides.