%0 Journal Article
%T Association of precursors with invasive adenocarcinoma of the gallbladder: A clinicopathological study.
%A Nakanuma Y
%A Sugino T
%A Nomura Y
%A Watanabe H
%A Terada T
%A Sato Y
%A Ohnishi Y
%A Nakanuma Y
%A Sugino T
%A Nomura Y
%A Watanabe H
%A Terada T
%A Sato Y
%A Ohnishi Y
%J Ann Diagn Pathol
%V 58
%N 0
%D Jun 2022
%M 35217489
%F 2.134
%R 10.1016/j.anndiagpath.2022.151911
%X <B>BACKGROUND: </B>The current WHO classification proposed high-grade biliary intraepithelial neoplasm (BilIN) and intracholecystic papillary neoplasm (ICPN) as precursors of the gallbladder carcinoma (GBC). Herein, conventional GBCs (cGBCs) were pathologically examined with respect to these two precursors.<BR><B>METHODS: </B>Forty-seven cases of GBC with grossly visible invasions were collected from Fukui Saiseikai Hospital. The association of two precursors was analyzed referring to pathologic features of cGBCs and post-operative survival.<BR><B>RESULTS: </B>20 cGBCa (42.6%) were associated with either of two precursors in the surrounding mucosa: high-grade BilIN in 15 cases (31.9%) or ICPN in 5 cases (10.6%). Association of precursors was not related to gross types of and histological differentiation of cGBC. cGBCs without precursors showed frequent vascular/perineural invasion and lymph node metastasis, though cGBCs with and without precursors presented a similar post-operative survival. High-grade BilIN and ICPN associated with cGBCs showed more complicated cytoarchitectural features compared with those with no or focal invasion.<BR><B>CONCLUSIONS: </B>More than 40% of cGBCs were associated with high-grade BilIN or ICPN, and the former was a frequent precursor. cGBCs without precursors showed aggressive pathologic features. Clinical detection of these precursors may make early treatment of cGBCs possible.