%0 Journal Article
%T Human pre-mRNA 3' end processing: reconstituting is believing.
%A Yoon Y
%A Shi Y
%J Genes Dev
%V 36
%N 3
%D 02 2022 1
%M 35193945
%F 12.89
%R 10.1101/gad.349453.122
%X It is every biochemist's dream to reconstitute a biological process in vitro using defined components, because doing so not only reduces a biological phenomenon to one or a series of biochemical reactions, but also defines the minimal list of essential components. In this issue of Genes & Development, Boreikaite and colleagues (pp. 210-224) and Schmidt and colleagues (pp. 195-209) report their independent reconstitution of human pre-mRNA 3' end processing.