%0 Case Reports
%T Concurrent Takayasu Arteritis and Vascular Ehlers-Danlos Syndrome: A Case Report.
%A Hashimoto K
%A Sakai R
%A Shibata A
%A Okada Y
%A Yoshinaga S
%A Kurasawa T
%A Kondo T
%A Amano K
%J Front Cardiovasc Med
%V 9
%N 0
%D 2022
%M 35155630
%F 5.846
%R 10.3389/fcvm.2022.805505
%X Takayasu arteritis (TAK) is a rare primary systemic inflammatory vasculopathy. It is classified as a large-vessel vasculitis and is known to cause inflammatory aneurysms and vascular stenosis. Vascular Ehlers-Danlos syndrome (vEDS) is an autosomal dominant condition known to cause multiple aneurysms and arterial dissection at a young age owing to a mutation in the gene for type III collagen, COL3A1. Here, we present a case of TAK associated with vEDS with the development of multi-organ infarction of the brain, kidney, and spleen owing to multiple arterial aneurysms and stenosis of the internal carotid artery. The patient was successfully treated using anti-inflammatory agents, glucocorticoids, and tocilizumab with the addition of interventional radiology. In our case, a high inflammatory response led to vasculitis being the main cause of the disease with concurrent vEDS. When patients develop multiple aneurysms, stenosis, and dissections leading to multiple organ infarctions, a systemic differential diagnosis to consider concurrent vasculitis syndrome and non-inflammatory vasculopathy, including hereditary disorders, is important even with time constraints.