%0 Journal Article
%T Different scaling and root planing strategies in Turkish patients with aggressive periodontitis: A randomized controlled clinical trial.
%A Mamaklıoğlu D
%A Karched M
%A Kuru L
%A Kuru B
%A Asikainen S
%A Doğan B
%J Int J Dent Hyg
%V 20
%N 2
%D May 2022
%M 35143714
%F 2.725
%R 10.1111/idh.12592
%X <B>OBJECTIVE: </B>The aim of this study was to compare clinical, cytokine and microbiological responses after quadrant-based scaling and root planing (Q-SRP), full-mouth SRP (FM-SRP) and full-mouth disinfection (FMD) in patients with generalized aggressive periodontitis (GAgP), which is currently termed as generalized stage-III and grade-C periodontitis.<BR><B>METHODS: </B>Forty-two patients with GAgP were randomly assigned into groups as Q-SRP, FM-SRP or FMD with chlorhexidine. Clinical parameters were recorded, and gingival crevicular fluid (GCF) and subgingival plaque samples were collected at baseline, 3 and 6 months after treatment. GCF levels of interleukin (IL)-1β and IL-17 were analysed using ELISA. Quantities of six bacterial species were determined using qPCR.<BR><B>RESULTS: </B>Clinical parameters improved significantly in all groups at 3 and 6 months (p < 0.05). Percentage of sites with probing depth >6 mm was lower in the FMD than Q-SRP group at 3 and 6 months (p < 0.05). FMD showed significantly higher percentage of pocket closure compared with Q-SRP and FM-SRP at both 3 and 6 months after treatment (p < 0.05). The IL-1β levels decreased only in the FMD group (p < 0.05), whereas no changes were found in IL-17 levels in any group. The levels of five out of six bacterial species decreased at 3 and/or 6 months only in the FMD group (p < 0.05).<BR><B>CONCLUSIONS: </B>The FMD treatment appears to offer superior outcome than Q-SRP and could be the first choice for patients with GAgP.