%0 Journal Article
%T Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients.
%A Nguyen B
%A Fong C
%A Luthra A
%A Smith SA
%A DiNatale RG
%A Nandakumar S
%A Walch H
%A Chatila WK
%A Madupuri R
%A Kundra R
%A Bielski CM
%A Mastrogiacomo B
%A Donoghue MTA
%A Boire A
%A Chandarlapaty S
%A Ganesh K
%A Harding JJ
%A Iacobuzio-Donahue CA
%A Razavi P
%A Reznik E
%A Rudin CM
%A Zamarin D
%A Abida W
%A Abou-Alfa GK
%A Aghajanian C
%A Cercek A
%A Chi P
%A Feldman D
%A Ho AL
%A Iyer G
%A Janjigian YY
%A Morris M
%A Motzer RJ
%A O'Reilly EM
%A Postow MA
%A Raj NP
%A Riely GJ
%A Robson ME
%A Rosenberg JE
%A Safonov A
%A Shoushtari AN
%A Tap W
%A Teo MY
%A Varghese AM
%A Voss M
%A Yaeger R
%A Zauderer MG
%A Abu-Rustum N
%A Garcia-Aguilar J
%A Bochner B
%A Hakimi A
%A Jarnagin WR
%A Jones DR
%A Molena D
%A Morris L
%A Rios-Doria E
%A Russo P
%A Singer S
%A Strong VE
%A Chakravarty D
%A Ellenson LH
%A Gopalan A
%A Reis-Filho JS
%A Weigelt B
%A Ladanyi M
%A Gonen M
%A Shah SP
%A Massague J
%A Gao J
%A Zehir A
%A Berger MF
%A Solit DB
%A Bakhoum SF
%A Sanchez-Vega F
%A Schultz N
%J Cell
%V 185
%N 3
%D 02 2022 3
%M 35120664
%F 66.85
%R 10.1016/j.cell.2022.01.003
%X Metastatic progression is the main cause of death in cancer patients, whereas the underlying genomic mechanisms driving metastasis remain largely unknown. Here, we assembled MSK-MET, a pan-cancer cohort of over 25,000 patients with metastatic diseases. By analyzing genomic and clinical data from this cohort, we identified associations between genomic alterations and patterns of metastatic dissemination across 50 tumor types. We found that chromosomal instability is strongly correlated with metastatic burden in some tumor types, including prostate adenocarcinoma, lung adenocarcinoma, and HR+/HER2+ breast ductal carcinoma, but not in others, including colorectal cancer and high-grade serous ovarian cancer, where copy-number alteration patterns may be established early in tumor development. We also identified somatic alterations associated with metastatic burden and specific target organs. Our data offer a valuable resource for the investigation of the biological basis for metastatic spread and highlight the complex role of chromosomal instability in cancer progression.