%0 Journal Article
%T Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective.
%A Raimondi R
%A Zollet P
%A De Rosa FP
%A Tsoutsanis P
%A Stravalaci M
%A Paulis M
%A Inforzato A
%A Romano MR
%J Int J Mol Sci
%V 23
%N 2
%D Jan 2022 8
%M 35054869
%F 6.208
%R 10.3390/ijms23020682
%X The retinal pigmented epithelium (RPE) plays a pivotal role in retinal homeostasis. It is therefore an interesting target to fill the unmet medical need of different retinal diseases, including age-related macular degeneration and Stargardt disease. RPE replacement therapy may use different cellular sources: induced pluripotent stem cells or embryonic stem cells. Cells can be transferred as suspension on a patch with different surgical approaches. Results are promising although based on very limited samples. In this review, we summarize the current progress of RPE replacement and provide a comparative assessment of different published approaches which may become standard of care in the future.