%0 Case Reports
%T Intensified Hyposensitization Is an Effective Treatment of Postorgasmic Illness Syndrome (POIS).
%A Wrotynska-Barczynska J
%A Swat E
%A Berger A
%A Pawelczyk L
%A Jedrzejczak P
%J Sex Med
%V 10
%N 2
%D Apr 2022
%M 35038623
%F 2.523
%R 10.1016/j.esxm.2021.100474
%X <B>BACKGROUND: </B>Postorgasmic illness syndrome (POIS) is an extremely rare urogenital disease which significantly and negatively impacts the functioning and sexual activity.<BR><B>OBJECTIVE: </B>A 34-year-old male presented with POIS symptoms and confirmed the allergic component of the POIS. Intensified immunotherapy with autologous semen was recommended.<BR><B>METHODS: </B>The treatment lasted 14 months and included 20 visits. Modified and intensified subcutaneous immunotherapy in both forearms significantly shortened the therapy and improved the outcome, with high-tolerance and no adverse effects or hyperactive responses.<BR><B>METHODS: </B>Improvement in POIS symptoms through the use of intensified immunotherapy with autologous semen.<BR><B>RESULTS: </B>The improvement was significant enough to allow for higher sexual activity, and gradual resumption of private and professional activity.<BR><B>CONCLUSIONS: </B>Intensified immunotherapy with autologous semen seems an effective and safe option for treating patients with suspected immune-allergenic POIS. To the best of our knowledge, this has been the first such intensive and effective allergen-specific immunotherapy of POIS. Wrotynska-Barczynska J, Swat. Swat E, Berger A, et al. Intensified Hyposensitization Is an Effective Treatment of Postorgasmic Illness Syndrome (POIS). Sex Med 2022;10:100474.