%0 Journal Article
%T Multiphoton Absorption Iridium(III)-Organotin(IV) Dimetal Complex with AIE Behavior for Both Sensitive Detection of Tyrosine and Antibacterial Activity.
%A Zhang Q
%A Lu X
%A Cao H
%A Wang H
%A Zhu T
%A Tian X
%A Li D
%A Zhou H
%A Wu J
%A Tian Y
%J ACS Appl Bio Mater
%V 3
%N 11
%D Nov 2020 16
%M 35019550
暂无%R 10.1021/acsabm.0c01206
%X Multiphoton absorption chromophores have emerged as an attractive class of fluorescent agents for bioimaging in recent years. Here, we first report a cyclometalated Iridium(III)-organotin(IV) dimetal complex, which exhibits efficient multiphoton (from two- to three-photon) fluorescence. The three-photon absorption of IrSn1 is located in the NIR-II (second near-infrared window (900-1700 nm)) region. IrSn1 obtained aggregation-induced emission (AIE), emitting bright orange fluorescence (595 nm). IrSn1 can specifically target tyrosine, which shows an obvious multiphoton fluorescence enhancement under NIR-II region. Importantly, IrSn1 is alsoprovided a visible antibacterial activity toward Staphylococcus aureus in vitro and in vivo. Two-photon fluorescence bioimages and stimulated emission depletion (STED) microscopy indicated that IrSn1 could specifically recognize the nuclear thus leading DNA breaking in Staphylococcus aureus and cancer cells.