%0 Journal Article
%T Single-dose antibiotic therapy for urinary infections during pregnancy: A systematic review and meta-analysis of randomized clinical trials.
%A Schulz GS
%A Schütz F
%A Spielmann FVJ
%A da Ros LU
%A de Almeida JS
%A Ramos JGL
%J Int J Gynaecol Obstet
%V 159
%N 1
%D Oct 2022
%M 34995367
%F 4.447
%R 10.1002/ijgo.14087
%X <B>BACKGROUND: </B>During pregnancy, urinary infections are an important cause of maternofetal morbidity and mortality and may lead to several complications.<BR><B>OBJECTIVE: </B>To verify whether the use of antibiotic therapy in a single dose when compared with multiple doses in lower tract urinary infections during pregnancy is effective to obtain microbiologic cure.<BR><B>METHODS: </B>Online databases were searched. Keywords used were "single-drug dose", "antibiotic", "fosfomycin", "amoxicillin", "trimethoprim", "pregnancy", and "urinary tract infection".<BR><B>METHODS: </B>Studies were included if they were randomized controlled trials, the population was pregnant woman, microbiologic cure was attained, and one of the treatment groups received single-dose antibiotic therapy.<BR><B>METHODS: </B>Preselected studies have been independently read by pairs, and data were extracted according to a predetermined sheet. The Cochrane tool was used for the risk of bias.<BR><B>RESULTS: </B>A total of 1063 women from nine studies were included. The primary outcome was the microbiologic cure attested by urine culture. When compared with the multiple-day use of antibiotics, the single-dose treatment has shown statistically similar results in reaching culture cure (odds ratio 1.02, 95% confidence interval 0.73-1.44).<BR><B>CONCLUSIONS: </B>The current study has shown that the use of single-dose treatment for lower tract urinary infections during pregnancy can be recommended, especially using fosfomycin.<BR><B>BACKGROUND: </B>This review has not been registered.