%0 Journal Article
%T Which mixed depression model? A comparison between DSM-5-defined mixed features and Koukopoulos' criteria.
%A Mineo L
%A Rodolico A
%A Spedicato GA
%A Aguglia A
%A Bolognesi S
%A Concerto C
%A Cuomo A
%A Goracci A
%A Serafini G
%A Maina G
%A Fagiolini A
%A Amore M
%A Aguglia E
%J Bipolar Disord
%V 0
%N 0
%D Nov 2021 30
%M 34846773
%F 5.345
%R 10.1111/bdi.13166
%X <B>BACKGROUND: </B>The criteria of the Diagnostic and Statistical Manual of Mental Disorders 5th edition "with mixed features specifier" (DSM-5 MFS) are considered controversial since they include only typical manic symptoms. By contrast, Koukopoulos developed an alternative model of mixed depression (MxD) focusing primarily on the excitatory component.<BR><B>OBJECTIVE: </B>To compare DSM-5 MFS and Koukopoulos' MxD (KMxD) in terms of prevalence, associated clinical variables, and discriminative capacity for bipolar depression in patients with major depressive episode (MDE).<BR><B>METHODS: </B>A total of 300 patients with MDE-155 with major depressive disorder and 145 with bipolar disorder (BD)-were recruited. The discriminative capacity of DSM-5 MFS and KMxD criteria for BD was estimated using the area under the curves of receiver operating characteristic (ROC_AUC). The clinical variables associated with these two diagnostic constructs were assessed by performing a logistic regression.<BR><B>RESULTS: </B>A total of 44 and 165 patients met the DSM-5 MFS and KMxD criteria, respectively. The ROC_AUCs and their confidence intervals for BD according to DSM-5 MFS and KMxD were 77.0% (72.0%-82.1%) and 71.9% (66.2%-77.7%), respectively. The optimal thresholds (combining sensitivity and specificity measures) for BD diagnosis were ≥1 (77%/68%) for DSM-5 MFS and ≥3 symptoms (78%/66%) for KMxD. However, considering the DSM-5 MFS cut-off (≥3 symptoms), the specificity (97%) increased at the expense of sensitivity (26%).<BR><B>CONCLUSIONS: </B>KMxD and DSM-5-MFS showed an overlapping discriminative capacity for bipolar depression. The current diagnostic threshold of DSM-5 MFS did not prove to be very inclusive, if compared with the greater diagnostic sensitivity of KMxD, which also yielded better association with clinical variables related to mixedness.