%0 Case Reports
%T Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report.
%A Kongsbak-Wismann M
%A Al-Jaberi FAH
%A Schmidt JD
%A Ghanizada M
%A Hansen CB
%A Lopez DV
%A Woetmann A
%A Ødum N
%A Bonefeld CM
%A Stryhn A
%A Garred P
%A Buus S
%A Geisler C
%J Front Immunol
%V 12
%N 0
%D 2021
%M 34659264
%F 8.786
%R 10.3389/fimmu.2021.758154
%X The coronavirus disease 2019 (COVID-19) pandemic has severely impacted daily life all over the world. Any measures to slow down the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to decrease disease severity are highly requested. Recent studies have reported inverse correlations between plasma levels of vitamin D and susceptibility to SARS-CoV-2 infection and COVID-19 severity. Therefore, it has been proposed to supplement the general population with vitamin D to reduce the impact of COVID-19. However, by studying the course of COVID-19 and the immune response against SARS-CoV-2 in a family with a mutated, non-functional vitamin D receptor, we here demonstrate that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family. Although these observations might not directly be transferred to the general population, they question a central role of vitamin D in the generation of adaptive immunity against SARS-CoV-2.