%0 Journal Article
%T 2020 WHO Classification of Female Genital Tumors.
%A Höhn AK
%A Brambs CE
%A Hiller GGR
%A May D
%A Schmoeckel E
%A Horn LC
%J Geburtshilfe Frauenheilkd
%V 81
%N 10
%D Oct 2021
%M 34629493
%F 2.754
%R 10.1055/a-1545-4279
%X The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading; however, the WHO classification does not recommend any specific grading system. VIN are also differentiated according to whether they are HPV(p16)-associated. HPV-independent adenocarcinoma (AC) of the cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression is considered to be a surrogate marker for HPV association. HPV-associated AC of the cervix uteri is determined using the prognostically relevant Silva pattern.