%0 Journal Article
%T Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms.
%A Frega G
%A Kepp O
%A Turchetti D
%A Rizzo A
%A Pantaleo MA
%A Brandi G
%J Transl Oncol
%V 14
%N 12
%D Dec 2021
%M 34592590
%F 4.803
%R 10.1016/j.tranon.2021.101224
%X The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field.