%0 Journal Article
%T Shining light on location-biased cAMP signaling.
%A Vilardaga JP
%A Sutkeviciute I
%A Peña KA
%J J Biol Chem
%V 297
%N 3
%D 09 2021
%M 34437901
暂无%R 10.1016/j.jbc.2021.101118
%X cAMP is the indispensable second messenger regulating cell metabolism and function in response to extracellular hormones and neurotransmitters. cAMP is produced via the activation of G protein-coupled receptors located at both the cell surface and inside the cell. Recently, Tsvetanova et al. explored cAMP generation in distinct locations and the impact on respective cell functions. Using a phospho-proteomic analysis, they provide insight into the unique role of localized cAMP production in cellular phospho-responses.