%0 Journal Article
%T Risk of Atrial Fibrillation According to Cancer Type: A Nationwide Population-Based Study.
%A Yun JP
%A Choi EK
%A Han KD
%A Park SH
%A Jung JH
%A Park SH
%A Ahn HJ
%A Lim JH
%A Lee SR
%A Oh S
%J JACC CardioOncol
%V 3
%N 2
%D Jun 2021
%M 34396327
%F 8.422
%R 10.1016/j.jaccao.2021.03.006
%X UNASSIGNED: Patients with cancer have an increased risk of atrial fibrillation (AF). However, there is a paucity of information regarding the association between cancer type and risk of AF.
UNASSIGNED: This study sought to evaluate the risk of AF according to the type of cancer.
UNASSIGNED: We enrolled 816,811 patients who were diagnosed with cancer from the Korean National Health Insurance Service database between 2009 and 2016. Age- and sex-matched noncancer control subjects (1:2; n = 1,633,663) were also selected. Newly diagnosed AF was identified based on the type of cancer.
UNASSIGNED: During a median follow-up of 4.5 years, AF was newly diagnosed in 25,356 patients with cancer (6.6 per 1,000 person-years). In multivariable Fine and Gray's regression analysis, cancer was an independent risk factor for incident AF (adjusted subdistribution hazard ratio [aHR]: 1.63; 95% confidence interval [CI]: 1.61 to 1.66). Multiple myeloma showed a higher association with incident AF (aHR: 3.34; 95% CI: 2.98 to 3.75). Esophageal cancer showed the highest risk among solid cancers (aHR: 2.69; 95% CI: 2.45 to 2.95), and stomach cancer showed the lowest association with AF risk (aHR: 1.27; 95% CI 1.23 to 1.32).
UNASSIGNED: Although patients with cancer were found to have a higher risk of AF, the impact on AF development varied by cancer type.