%0 Case Reports
%T Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma.
%A Zhou X
%A Zhou YN
%A Ali A
%A Liang C
%A Ye Z
%A Chen X
%A Zhang Q
%A Deng L
%A Sun X
%A Zhang Q
%A Luo J
%A Li W
%A Zhou K
%A Cao S
%A Zhang X
%A Li XD
%A Zhang XE
%A Cui Z
%A Men D
%J Front Immunol
%V 12
%N 0
%D 2021
%M 34394095
%F 8.786
%R 10.3389/fimmu.2021.701295
%X The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.