%0 Journal Article
%T Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells.
%A Duan Y
%A Qi D
%A Liu Y
%A Song Y
%A Wang X
%A Jiao S
%A Li H
%A Gonzalez FJ
%A Qi Y
%A Xu Q
%A Du J
%A Qu A
%J Biochem Biophys Rep
%V 27
%N 0
%D Sep 2021
%M 34381883
暂无%R 10.1016/j.bbrep.2021.101091
%X Peroxisome proliferator-activated receptor (PPAR) α is widely expressed in the vasculature and has pleiotropic and lipid-lowering independent effects, but its role in the growth and function of vascular smooth muscle cells (VSMCs) during vascular pathophysiology is still unclear. Herein, VSMC-specific PPARα-deficient mice (Ppara ΔSMC) were generated by Cre-LoxP site-specific recombinase technology and VSMCs were isolated from mice aorta. PPARα deficiency attenuated VSMC apoptosis induced by angiotensin (Ang) II and hydrogen peroxide, and increased the migration of Ang II-challenged cells.