%0 Journal Article
%T Analysis of interferon type I signature for differential diagnosis of diseases of the immune system ( review of literature).
%A Suspitsin EN
%A Raupov RK
%A Kuchinskaya EM
%A Kostik MM
%J Klin Lab Diagn
%V 66
%N 5
%D May 2021 23
%M 34047513
暂无%R 10.51620/0869-2084-2021-66-5-279-284
%X Type 1 interferons (IFN1) are both key molecules of antiviral defense and potent inflammatory mediators. In 2003, increased expression of a variety of interferon 1-regulated genes was observed in a blood cells of patients with systemic lupus erythematosus (SLE). This phenomenon was called the type 1 interferon signature (IFN1-signature). Since then, expression patterns indicating the presence of an IFN1-signature were consistently detected in a range of monogenic and complex autoimmune and autoinflammatory conditions. A quantitative indicator reflecting the degree of hyperactivation of the IFN1 pathway is known as interferon score. This review discusses the possible causes of upregulated expression of interferon 1-induced genes, the laboratory approaches to the interferon score analysis, as well as the practical use of this indicator for the diagnosis of various conditions.