%0 Journal Article
%T The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems.
%A Yang C
%A He B
%A Dai W
%A Zhang H
%A Zheng Y
%A Wang X
%A Zhang Q
%J Acta Pharm Sin B
%V 11
%N 4
%D Apr 2021
%M 33996409
%F 14.903
%R 10.1016/j.apsb.2020.11.020
%X As one of the most important components of caveolae, caveolin-1 is involved in caveolae-mediated endocytosis and transcytosis pathways, and also plays a role in regulating the cell membrane cholesterol homeostasis and mediating signal transduction. In recent years, the relationship between the expression level of caveolin-1 in the tumor microenvironment and the prognostic effect of tumor treatment and drug treatment resistance has also been widely explored. In addition, the interplay between caveolin-1 and nano-drugs is bidirectional. Caveolin-1 could determine the intracellular biofate of specific nano-drugs, preventing from lysosomal degradation, and facilitate them penetrate into deeper site of tumors by transcytosis; while some nanocarriers could also affect caveolin-1 levels in tumor cells, thereby changing certain biophysical function of cells. This article reviews the role of caveolin-1 in tumor prognosis, chemotherapeutic drug resistance, antibody drug sensitivity, and nano-drug delivery, providing a reference for the further application of caveolin-1 in nano-drug delivery systems.