%0 Journal Article
%T Multimechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection.
%A Mao Y
%A Valour F
%A Nguyen NTQ
%A Doan TMN
%A Koelkebeck H
%A Richardson C
%A Cheng LI
%A Sellman BR
%A Tkaczyk C
%A Diep BA
%J Antimicrob Agents Chemother
%V 65
%N 7
%D 06 2021 17
%M 33903108
%F 5.938
%R 10.1128/AAC.01832-20
%X In a rabbit model of methicillin-resistant Staphylococcus aureus prosthetic joint infection (PJI), prophylaxis with AZD6389*-a combination of three monoclonal antibodies targeting alpha-hemolysin, bicomponent cytotoxins (LukSF/LukED/HlgAB/HlgCB), and clumping factor A-resulted in significant reductions in joint swelling, erythema, intra-articular pus, and bacterial burden in synovial tissues and biofilm-associated prosthetic implants compared with isotype-matched control IgG. Targeting specific staphylococcal virulence factors may thus have potential clinical utility for prevention of PJI.