%0 Case Reports
%T Invasive cerebral phaeohyphomycosis in a Chinese boy with CARD9 deficiency and showing unique radiological features, managed with surgical excision and antifungal treatment.
%A Lai SHY
%A Duque JSR
%A Chung BH
%A Chung TW
%A Leung D
%A Ho RS
%A Lee R
%A Poon RWS
%A Chua GT
%A Cheong KN
%A Chui MMC
%A Lee M
%A Tam S
%A Him AHC
%A Cheng KF
%A Ho WW
%A Yuen KY
%A Lee P
%A Lau YL
%J Int J Infect Dis
%V 107
%N 0
%D Jun 2021
%M 33872781
%F 12.074
%R 10.1016/j.ijid.2021.04.052
%X We report this rare case of cerebral phaeohyphomycosis in a previously healthy Chinese boy, who was found to have caspase recruitment domain family member 9 (CARD9) deficiency. Initial radiological features suggested a neoplastic cerebral lesion, while histopathological examination supplemented by internal transcribed sequencing (ITS) of cerebral tissue confirmed the diagnosis of phaeohyphomycosis. He was treated with intravenous (IV) liposomal amphotericin B and voriconazole, guided by plasma and cerebrospinal fluid (CSF) level monitoring at drug initiation. At the 1 year follow-up, the patient demonstrated near complete neurological and radiological recovery.