%0 Journal Article
%T Guideline for the use of immunobiologicals in chronic rhinosinusitis with nasal polyps (CRSwNP) in Brazil.
%A Anselmo-Lima WT
%A Tamashiro E
%A Romano FR
%A Miyake MM
%A Roithmann R
%A Kosugi EM
%A Nakanishi M
%A Fornazieri MA
%A Bezerra TFP
%A Mello JF
%A Lessa MM
%A Voegels RL
%A Piltcher OB
%A Sakano E
%A Valera FCP
%J Braz J Otorhinolaryngol
%V 0
%N 0
%D Apr 2021 3
%M 33867274
%F 2.474
%R 10.1016/j.bjorl.2021.03.003
%X <B>BACKGROUND: </B>Severe uncontrolled chronic rhinosinusitis with nasal polyps has a negative impact on an individual's quality of life. Therefore, new biologics have emerged for use in specific phenotypes of chronic rhinosinusitis, changing the paradigms of its treatment.<BR><B>OBJECTIVE: </B>To review the current status of biologic treatment indications in chronic rhinosinusitis.<BR><B>METHODS: </B>The Brazilian Academy of Rhinology brought together different specialists to suggest a course of action, considering its particularities and aspects related to the national reality.<BR><B>RESULTS: </B>Of particular interest for decision making will be the identification of subgroups of patients refractory to pre-existing treatment options and the construction of a strategy that improves their quality of life, with the best cost-benefit ratio.<BR><B>CONCLUSIONS: </B>The use of biologics is a valid option for treatment in more severe cases. This strategy must be better understood and improved in the future, with more studies and greater clinical experience.