%0 Journal Article
%T Prediction model that combines with multidisciplinary analysis for clinical evaluation of malignancy risk of solid breast nodules.
%A Dong B
%A Hu Q
%A He H
%A Liu Y
%J J Int Med Res
%V 49
%N 4
%D Apr 2021
%M 33845599
%F 1.573
%R 10.1177/03000605211004681
%X <B>OBJECTIVE: </B>Few studies have systematically developed predictive models for clinical evaluation of the malignancy risk of solid breast nodules. We performed a retrospective review of female patients who underwent breast surgery or puncture, aiming to establish a predictive model for evaluating the clinical malignancy risk of solid breast nodules.<BR><B>METHODS: </B>Multivariable logistic regression was used to identify independent variables and establish a predictive model based on a model group (207 nodules). The regression model was further validated using a validation group (112 nodules).<BR><B>RESULTS: </B>We identified six independent risk factors (X3, boundary; X4, margin; X6, resistive index; X7, S/L ratio; X9, increase of maximum sectional area; and X14, microcalcification) using multivariate analysis. The combined predictive formula for our model was: Z=-5.937 + 1.435X3 + 1.820X4 + 1.760X6 + 2.312X7 + 3.018X9 + 2.494X14. The accuracy, sensitivity, specificity, missed diagnosis rate, misdiagnosis rate, negative likelihood ratio, and positive likelihood ratio of the model were 88.39%, 90.00%, 87.80%, 10.00%, 12.20%, 7.38, and 0.11, respectively.<BR><B>CONCLUSIONS: </B>This predictive model is simple, practical, and effective for evaluation of the malignancy risk of solid breast nodules in clinical settings.