%0 Comparative Study
%T Breast Textured Implants Determine Early T-helper Impairment: BIAL2.20 Study.
%A Vanni G
%A Materazzo M
%A Pellicciaro M
%A Amir S
%A Tacconi F
%A Ambrogi V
%A Buonomo OC
%J Anticancer Res
%V 41
%N 4
%D Apr 2021
%M 33813423
%F 2.435
%R 10.21873/anticanres.14984
%X <B>OBJECTIVE: </B>Surgical stress has been correlated with higher rate of postoperative complications. Breast implants' surfaces (textured or smooth) represent an immunological stimulus. Our prospective study (BIAL2.20) evaluated post-operative leukocytes response at baseline and postoperative day (POD) 1 and 2 after implant-based breast reconstruction.<BR><B>METHODS: </B>Between January and July 2020, 41 patients underwent reconstruction with textured (n=23) or smooth (n=18) implants. A full blood count and lymphocyte subsets were collected before surgery, on POD1 and POD2. Data were evaluated as difference and relative difference from baseline by two-way analysis of variance test (2-way-ANOVA). Mann-Whitney U-test was performed at each POD, whenever between-group 2-way-ANOVA reached statistical significance.<BR><B>RESULTS: </B>Within-group-analysis showed statistically significant total leukocytosis in both groups. Within-group-analysis of lymphocytes subsets demonstrated statistically significant lymphopenia in the textured group for T-lymphocytes, and T-helper cells. Between-group-analysis showed statistically significant lymphopenia in T-helper subsets in the textured group at POD1 and POD2, when compared with the smooth group.<BR><B>CONCLUSIONS: </B>Textured implants demonstrated a statistically significant impairment of T-helper trend during POD1 and POD2 when compared to smooth implants by between-group 2-way-ANOVA.