%0 Journal Article
%T Infectious complications associated with short-term mechanical circulatory support in urgent heart transplant candidates.
%A Solla-Buceta M
%A González-Vílchez F
%A Almenar-Bonet L
%A Lambert-Rodríguez JL
%A Segovia-Cubero J
%A González-Costello J
%A Delgado JF
%A Pérez-Villa F
%A Crespo-Leiro MG
%A Rangel-Sousa D
%A Martínez-Sellés M
%A Rábago-Juan-Aracil G
%A De-la-Fuente-Galán L
%A Blasco-Peiró T
%A Hervás-Sotomayor D
%A Garrido-Bravo IP
%A Mirabet-Pérez S
%A Muñiz J
%A Barge-Caballero E
%J Rev Esp Cardiol (Engl Ed)
%V 0
%N 0
%D Feb 2021 26
%M 33648882
暂无%R 10.1016/j.rec.2020.11.019
%X OBJECTIVE: Short-term mechanical circulatory support is frequently used as a bridge to heart transplant in Spain. The epidemiology and prognostic impact of infectious complications in these patients are unknown.
METHODS: Systematic description of the epidemiology of infectious complications and analysis of their prognostic impact in a multicenter, retrospective registry of patients treated with short-term mechanical devices as a bridge to urgent heart transplant from 2010 to 2015 in 16 Spanish hospitals.
RESULTS: We studied 249 patients, of which 87 (34.9%) had a total of 102 infections. The most frequent site was the respiratory tract (n=47; 46.1%). Microbiological confirmation was obtained in 78 (76.5%) episodes, with a total of 100 causative agents, showing a predominance of gram-negative bacteria (n=58, 58%). Compared with patients without infection, those with infectious complications showed higher mortality during the support period (25.3% vs 12.3%, P=.009) and a lower probability of receiving a transplant (73.6% vs 85.2%, P=.025). In-hospital posttransplant mortality was similar in the 2 groups (with infection: 28.3%; without infection: 23.4%; P=.471).
CONCLUSIONS: Patients supported with temporary devices as a bridge to heart transplant are exposed to a high risk of infectious complications, which are associated with higher mortality during the organ waiting period.