%0 Case Reports
%T Treatment of pediatric intracranial dissecting aneurysm with clipping and angioplasty, and next-generation sequencing analysis: A case report and literature review.
%A Sun N
%A Yang XY
%A Zhao Y
%A Zhang QJ
%A Ma X
%A Wei ZN
%A Li MQ
%J World J Clin Cases
%V 9
%N 5
%D Feb 2021 16
%M 33644173
%F 1.534
%R 10.12998/wjcc.v9.i5.1103
%X <B>BACKGROUND: </B>Large intracranial dissecting aneurysm (IDA) in the anterior cerebral circulation is rare in children. There has been no consensus on the diagnosis and treatment for IDA in children.<BR><B>METHODS: </B>We report a 3-year-old boy with a large ruptured IDA in the right middle cerebral artery (16 mm × 14 mm). The IDA was successfully managed with clipping and angioplasty. Next-generation sequencing of the blood sample followed by bioinformatics analysis suggested that the rs78977446 variant of the ADAMTS13 gene is a risk for pediatric IDA. Three years after surgery, the boy was develop-mentally normal.<BR><B>CONCLUSIONS: </B>Clipping and angioplasty are effective treatments for ruptured IDA in the anterior cerebral circulation. ADAMTS13 rs78977446 is a risk factor for pediatric IDA.