%0 Clinical Trial
%T Assessing the effectiveness of the combination therapy with fractional Er-YAG laser and platelet-rich plasma in treatment of periorbital dark circles patients: A clinical trial.
%A Nilforoushzadeh MA
%A Heidari-Kharaji M
%A Alavi S
%A Mahmoudbeyk M
%A Torkamaniha E
%A Peyrovan A
%A Nouri M
%A Zare S
%J J Cosmet Dermatol
%V 20
%N 11
%D Nov 2021
%M 33638928
%F 2.189
%R 10.1111/jocd.14036
%X <B>BACKGROUND: </B>Numerous therapeutic techniques for periorbital hyperpigmentation have been suggested.<BR><B>OBJECTIVE: </B>In this comparative intrapatient study, the effectiveness of combination therapy included fractional Er: YAG laser and autologous platelet-rich plasma (PRP) compared to Er: YAG laser in periorbital hyperpigmentation treatment.<BR><B>METHODS: </B>Thirty-two patients were enrolled. The right periorbital sides of patients received combination of Er: YAG laser and autologous platelet-rich plasma (PRP) and the left side received Er: YAG laser (three sessions with 4 weeks' intervals). PRP was used in two ways included injection and topical. Patients were evaluated by biometric characteristics, patients, and physician assessments. Also, the patient's satisfaction was assessed and side effects were evaluated.<BR><B>RESULTS: </B>The mexameter results showed that the melanin content in the right side of the periorbital of the patients was significantly decreased compared to left side. Also, significant increase was observed in the skin lightness of the right side in compare to left. The visioface results showed the decrease in the percent change of the color and wrinkle in both sides, but in the right side these changes were significantly more than left side. The patients and physician assessment confirmed the measured results.<BR><B>CONCLUSIONS: </B>Combination of Er: YAG laser and PRP is significantly effective for periorbital hyperpigmentation.