%0 Journal Article
%T GST T1, M1, and IRS-1 G972R Genetic Variants Association to Gestational Diabetes Mellitus (GDM) in Egyptian women: Linkage to Maternal Hyperglycemia.
%A Barseem NF
%A Khattab E
%A Dawood R
%A Mohamed S
%J Curr Diabetes Rev
%V 0
%N 0
%D Feb 2021 19
%M 33605864
暂无%R 10.2174/1573399817666210219124628
%X <B>BACKGROUND: </B>Gestational diabetes mellitus (GDM) shares in part pathogenic mechanisms of multiple genetic interactions. Some ofT2D susceptibility genes are encountered in association with GDM.<BR><B>OBJECTIVE: </B>We aimed to investigate for GST T1, M1 and G972R IRS-I gene polymorphisms with the risk of developing GDM.<BR><B>METHODS: </B>In this randomized case-control study, pregnant women with GDM were genotyped for by PCR analysis for glutathione s-transferase-T1, M1 variant polymorphisms. RFLP was done for the G972R IRS 1 gene. Their newborns were additionally assayed for whole of the clinical, laboratory and genetic aspects.<BR><B>RESULTS: </B>The T allele, IRS-1rs1801278 TT genotype were frequently detected in GDM mothers in comparison to healthy control ones [for TT homozygous variant; OR(CI 95%): 2.05(1.09-3.87, p: 0.025].Furthermore, GST T1 null was significantly presented in GDM mothers than those of control mother [OR (CI95%: 0.29 (0.084-1.02), p:0.04].Added to the significant correlation of glycemic indices to clinical parameters of infants born to GDM, M1-null genotype of GST was significantly correlated (p<0.05) to abnormal values of respiratory rates and 1 minute-APGAR scores noted for extra NICU care.<BR><B>CONCLUSIONS: </B>Our results suggested GST T1null and IRS-1 TT genotypic variants were claimed for GDM development among Egyptian women with possible impact on their newly born infants.