%0 Journal Article
%T Employing Photocatalysis for the Design and Preparation of DNA-Encoded Libraries: A Case Study.
%A Kölmel DK
%A Zhu H
%A Flanagan ME
%A Sakata SK
%A Harris AR
%A Wan J
%A Morgan BA
%J Chem Rec
%V 21
%N 4
%D Apr 2021
%M 33570227
%F 6.935
%R 10.1002/tcr.202000148
%X This Personal Account describes the authors' foray into DNA-encoded libraries. The article addresses several key aspects of this hit generation technology, from the development of new synthetic methodology to the subsequent conception, design, and delivery of a DNA-encoded library. In particular, we have been engaged in adapting photocatalytic reactions to the idiosyncratic requirements of DNA-encoded chemistry. We have chosen one such methodology, namely a photocatalytic [2+2] cycloaddition reaction, to showcase how we employed property-based computational analyses to guide the selection and validation of building blocks for the production of a library. Ultimately, these novel bond disconnections and design principles led to the assembly of a DNA-encoded library that is composed of structurally diverse compounds within largely desirable property space and, therefore, well positioned to deliver novel chemical matter for drug discovery programs.