%0 Journal Article
%T Are developmentally missing teeth a predictive risk marker of malignant diseases in non-syndromic individuals? A systematic review.
%A Al-Muzian L
%A Almuzian M
%A Mohammed H
%A Ulhaq A
%A Keightley AJ
%J J Orthod
%V 48
%N 3
%D 09 2021
%M 33455496
暂无%R 10.1177/1465312520984166
%X Different genes and loci that are associated with non-syndromic developmental tooth agenesis (TA) have the same causation pathway in the development of tumours including breast cancer (BC), epithelial ovarian cancer (EOC), colorectal cancer (CRC) and lung cancer (LC).<BR>To assess the link between TA and the development of cancer.<BR>This registered review included a comprehensive search of electronic databases (Cochrane Central Register of Controlled Trials [CENTRAL], LILACS, Scopus, Web of Science and Medline via Ovid) until 1 April 2020, supplemented by manual, grey literature and reference lists search. There was no restriction in term of date of publication, gender, race or type of hypodontia.<BR>The primary outcome was the relationship between TA and cancer. The secondary outcome was to identify the genetic correlation between TA and cancer.<BR>Study selection, data extraction and risk of bias assessment were performed independently and induplicate by two reviewers, with disputes resolved by a third reviewer.<BR>Eight studies with a moderate-high risk of bias were included in the final review, with a total of 5821 participants. Due to the heterogeneity among the included studies, the data were presented narratively. Limited studies reported a high prevalence of EOC (19.2%-20%) and CRC (82%-100%) in individuals with TA (depending on the study) compared to those without TA (3% for EOC and 0% for CRC). While others reported a weak correlation between EOC and CRC and TA (P > 0.05). Weak evidence suggested a strong correlation between breast, cervical uterine and prostate cancers and TA (P < 0.05).<BR>Though low-quality evidence suggests a link between TA and cancer, it was not possible to verify that TA can hold a predictive value as a marker for cancers. Further research is needed to confirm the association.<BR>PROSPERO (CRD42020139751).