%0 Journal Article
%T Synthesis and preliminary evaluation of a PET-FI bimodal imaging agent targeting estrogen receptor.
%A Cheng X
%A Yang Z
%A Sun Y
%A Zheng W
%A Chen H
%A Liu Y
%A Wu Z
%J Bioorg Med Chem Lett
%V 34
%N 0
%D 02 2021 15
%M 33418064
%F 2.94
%R 10.1016/j.bmcl.2021.127776
%X Estrogen receptor is an attractive target for the diagnosis and treatment of breast cancer. This article reports for the first time a dual-modality imaging agent targeting estrogen receptor that can use PET imaging to diagnose breast cancer and utilize fluorescence imaging to achieve intraoperative navigation. Fluorescence experiments show that [natGa] 1 has typical aggregate induced emission characteristics. Above the critical concentration, [natGa] 1 can form biocompatible nanomicelles. [natGa] 1 can quickly light up estrogen receptor positive MCF-7 cells. Cell uptake experiments show that [68Ga] 1 is mediated by estrogen receptor. Therefore, [nat/68Ga] 1 shows the characteristics of highly sensitive diagnosis and visualization of breast cancer, and can be used as a lead compound for the development of a novel PET-FI bimodal imaging agent targeting the estrogen receptor.