%0 Journal Article
%T SEOM Clinical Guideline of management of soft-tissue sarcoma (2020).
%A de Juan Ferré A
%A Álvarez Álvarez R
%A Casado Herráez A
%A Cruz Jurado J
%A Estival González A
%A Martín-Broto J
%A Martínez Marín V
%A Moreno Vega A
%A Sebio García A
%A Valverde Morales C
%J Clin Transl Oncol
%V 23
%N 5
%D May 2021
%M 33405052
%F 3.34
%R 10.1007/s12094-020-02534-0
%X Soft-tissue sarcomas constitute an uncommon and heterogeneous group of tumors of mesenchymal origin. Diagnosis, treatment, and management should be performed by an expert multidisciplinary team. MRI/CT of the primary tumor and biopsy is mandatory before any treatment. Wide surgical resection with tumor-free tissue margin is the mainstay for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not suitable for re-excision. Perioperative chemotherapy should be discussed for high-risk sarcomas of the extremities and trunk-wall. In the case of oligometastatic disease, patients should be considered for local therapies. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. Other drugs have shown activity in second-line therapy and in specific histological subtypes but options are limited and thus, a clinical trial should always be discussed.