%0 Journal Article
%T Relationship between expression mRNA gene Treg, Treg, CD4+, and CD8+ protein levels with TST in tuberculosis children: A nested case-control.
%A Farsida 
%A Shabariah R
%A Hatta M
%A Patellongi I
%A Prihantono 
%A Nasrum Massi M
%A Asadul Islam A
%A Natzir R
%A Dwi Bahagia Febriani A
%A Hamid F
%A Fatimah 
%A Akaputra R
%A Aprilia Savitri P
%J Ann Med Surg (Lond)
%V 61
%N 0
%D Jan 2021
%M 33384873
暂无%R 10.1016/j.amsu.2020.12.011
%X <B>UNASSIGNED: </B>The ability of Mycobacterium tuberculosis to survive intracellularly, provides a cellular adaptive immune response played by specific T cells to defend against tuberculosis. The adaptive immune response to Bacillus of Calmette and Guerin (BCG) immunization is responded to by B cells, T Follicular B helper, T regulatory, restriction CD1, CD8+, CD4+, Th1, Th2, and Th17. BCG immunization can cause a tuberculin test reaction to being positive. The tuberculin test is a method for diagnosing TB infection and for screening individuals for latent infection and assessing the rate of TB infection in a given population.<BR><B>UNASSIGNED: </B>a nested case-control survey was conducted on patients with a diagnosis of TB and parents 0-18 years of age from 3 hospitals in Indonesia during September-November 2019 with a total sample of 69 people undergoing clinical examinations, supporting and diagnosing subjects, blood sampling 1-2 cc for examination mRNA gene Treg, Treg, CD 4+, and CD 8+, then centrifuged at 3000 rpm for 10 min to support blood cells and serum.<BR><B>UNASSIGNED: </B>There was a significant relationship between expression of mRNA gene Treg with TST (p = 0,000), Treg with TST (p = 0,000), and CD4+ with TST (p = 0,000). Meanwhile, CD8 + was not significantly associated with TST (p = 0.118).<BR><B>UNASSIGNED: </B>It is necessary to check the expression of mRNA gene Treg, Treg, CD4+, and CD8+ with more samples to find the mean value that shows the protective value of further TB.