%0 Journal Article
%T The uteroplacental contact zone cytokine influence on NK cell cytotoxicity to trophoblasts.
%A Bazhenov D
%A Mikhailova V
%A Nikolaenkov I
%A Markova K
%A Salloum Z
%A Kogan I
%A Gzgzyan A
%A Selkov S
%A Sokolov D
%J Gynecol Endocrinol
%V 36
%N 0
%D 2020
%M 33305669
%F 2.277
%R 10.1080/09513590.2020.1816715
%X <B>OBJECTIVE: </B>The present study was to estimate the role of cytokines for trophoblast death in NK cells presence.<BR><B>METHODS: </B>This study involves assessment of NK-92 line NK cell cytotoxic activity against JEG-3 line cells, in presence of cytokines. We also assessed the effect of secretory placenta products on NK cell cytotoxic activity toward JEG-3 line cells.<BR><B>RESULTS: </B>Uteroplacental contact zone cytokines are able to enhance trophoblast mortality both by themselves in case of IL-1β, IL-6, IFNγ, IL-4, TGFβ, bFGF, and also through increasing the cytotoxic potential of NK cells in case of IL-1β, IFNγ, IL-8, TGFβ, and GM-CSF. PLGF decreases NK cell cytotoxicity for trophoblasts. Secretory products of first trimester placenta enhance NK cell cytotoxic potential for trophoblasts.<BR><B>CONCLUSIONS: </B>Cytokines of the uteroplacental contact zone can appear a mechanism ensuring trophoblast mortality dynamics throughout pregnancy.