%0 Journal Article
%T Impact of renal function on the prognosis of acute pulmonary embolism patients: a systematic review and meta-analysis.
%A Xing X
%A Liu J
%A Deng Y
%A Xu S
%A Wei L
%A Yang M
%A He X
%A Cao B
%A Huang X
%A Yue Q
%A Yang J
%A Teng Z
%J Expert Rev Respir Med
%V 0
%N 0
%D Dec 2020 31
%M 33297795
%F 4.3
%R 10.1080/17476348.2021.1862653
%X <B>UNASSIGNED: </B>We conduct a study to explore the influence of impaired renal function on prognosis in Acute pulmonary embolism (APE) patients.<BR><B>UNASSIGNED: </B>A meta-analysis was performed using the EMBASE and PubMed databases for relevant publications reporting the impact of impaired renal function on the clinical outcomes in patients with APE.<BR><B>UNASSIGNED: </B>Eventually, 17 articles were included in our analysis. The results suggested that renal insufficiency (RI) is a predictor of poor prognosis in APE patients(short-term mortality: pooled OR = 2.83, 95%CI: 2.20-3.63; long-term mortality: pooled OR = 2.30, 95%CI: 1.72-3.08; adverse outcomes: pooled OR = 3.02, 95%CI: 2.60-3.51). The short-term and long-term mortality rates of APE patients with RI were both higher than those in patients without RI. In addition, acute kidney injury(AKI) could serve as a predictive factor of poor prognosis (pooled OR = 2.75, 95%CI: 2.45-3.08), and it doubles the overall mortality rate in APE patients. However, chronic kidney disease (CKD) did not predict poor prognosis in APE patients (pooled OR = 1.94, 95%CI: 0.99-3.81), although it could slightly increase the overall mortality rate in APE patients.<BR><B>UNASSIGNED: </B>RI and AKI could be included in the prognosis evaluation for APE, but the impact of CKD in APE patients has yet to be determined.