%0 Journal Article
%T [Updating in prescription of proton pump inhibitors. What to do and what not to do].
%A Saiz Ladera GM
%A Pejenaute Labari ME
%A García Pascual JN
%J Semergen
%V 47
%N 4
%D May-Jun 2021
%M 33223372
暂无%R 10.1016/j.semerg.2020.09.011
%X <B>BACKGROUND: </B>Proton pump inhibitors (PPIs) are the most prescribed pharmacological subgroup of the National Health System and their use has been related to possible potentially serious adverse effects.<BR><B>OBJECTIVE: </B>To review the current indications for treatment with PPIs as well as the data related to their safety, in order to promote their adecuate use.<BR><B>METHODS: </B>A review of the literature focused on the following topics has been carried out: a) molecules and mechanism of action; b) current indications for treatment and adherence to them; c) adverse effects related to its use; d) drug interactions; e) alternatives in deprescription.<BR><B>RESULTS: </B>The current indications have not changed substantially in recent years and are well established, however, there is a high percentage of inappropriate prescription, mainly in individuals with low or no risk.<BR><B>CONCLUSIONS: </B>PPIs are safe drugs and generally well tolerated and their benefits are higher than possible adverse effects. Adhering to evidence-based recommendations represents the only rational approach to safe and effective therapy.