%0 Journal Article
%T Potential Mobilization of mcr-10 by an Integrative Mobile Element via Site-Specific Recombination in Cronobacter sakazakii.
%A Yang J
%A Liu L
%A Feng Y
%A He D
%A Wang C
%A Zong Z
%J Antimicrob Agents Chemother
%V 65
%N 2
%D 01 2021 20
%M 33199393
%F 5.938
%R 10.1128/AAC.01717-20
%X mcr-10 is a newly identified plasmid-borne colistin resistance gene, but its mobilization mechanism remains unclear. In this study, mcr-10 was found on an IncFIB plasmid carrying virulence genes mrkABCDFJ, iucABCD/iutA, and eitCBAD in a Cronobacter sakazakii isolate. By comparison with closely related plasmids, two recombination sites were identified flanking the genetic element containing mcr-10 and an integrase-encoding gene, suggesting that site-specific recombination mediated by an integrase of an integrative mobile element is a potential mechanism for mobilizing mcr-10.