%0 Case Reports
%T Very Late Relapse in Pediatric Acute Myeloid Leukemia: A Case Report and Brief Literature Review.
%A Unis GD
%A VanderVeen N
%A Fletcher M
%A Vasquez RJ
%J J Pediatr Hematol Oncol
%V 43
%N 6
%D 08 2021 1
%M 33136777
%F 1.17
%R 10.1097/MPH.0000000000001989
%X Acute myeloid leukemia (AML) is a heterogenous group of diseases affecting ~500 children in the United States annually. With current therapy, 90% of these children will obtain complete remission. However, 30% to 40% of these patients will relapse, most commonly within the first 3 years. Very late relapses, defined as relapse occurring >5 years after complete remission, are rare, accounting for 1% to 3% of relapses. We describe a patient with AML harboring an AFDN/KMT2A translocation who relapsed 12 years after matched sibling stem cell transplant, provide a brief review of the relevant literature, and describe proposed mechanisms to explain very late relapse AML.