%0 Case Reports
%T Synchronous diagnosis of anaplastic large cell lymphoma and multiple myeloma in a patient: A case report.
%A Shi X
%A Wu J
%A Jiang Q
%A Zhang S
%A Chen W
%A Yu X
%A Liu Y
%A Chen M
%A Peng J
%A Li T
%A Zhu Y
%A Xi X
%J Medicine (Baltimore)
%V 99
%N 44
%D Oct 2020 30
%M 33126356
%F 1.817
%R 10.1097/MD.0000000000022931
%X <B>BACKGROUND: </B>Synchronous development of both anaplastic large cell lymphoma (ALCL) and multiple myeloma (MM) in a patient is rare. To our knowledge, until now only one case has been reported. Treatment needs to cover both and is a challenge. Here we reported another case and discussed the diagnosis and treatment.<BR><B>UNASSIGNED: </B>This is a 63-year old woman who presented with a mass in upper abdominal skin. Positron emission tomography/computed tomography (PET/CT) showed the high metabolism in left abdominal skin and left axillary lymph nodes. Histopathologic and immunohistochemical evaluation identified the cutaneous mass as an ALK-negative ALCL. Bone marrow smear showed increased plasma cells which expressed CD38, CD138, and cLambda concomitantly. The increased monoclonal immunoglobulin IgD λ was detected by immunofixation electrophoresis.<BR><B>UNASSIGNED: </B>Diagnosis of both ALCL and MM was confirmed.<BR><B>METHODS: </B>The patient successively received 6 cycles of B-CHOD regimen, one cycle of ID regimen, 2 cycles of DHAX regimen, one cycle of L-DA-EPOCH and autologous stem cell transplantation (ASCT). Then lenalidomide was performed as a maintenance therapy.<BR><B>RESULTS: </B>Both ALCL and MM achieved complete remission.<BR><B>CONCLUSIONS: </B>We reported a very rare case with synchronous development of ALCL and MM, in whom a good therapeutic response to chemotherapies followed by ASCT has been observed.